Hello Bio/K-252a/HB0351/1mg
商品编号：
HB0351-1mg
品牌：
hellobio
市场价：
¥7546.50
美元价：
5805.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameK-252a
- ShortdescriptionNon-selectiveproteinkinaseinhibitor
- BIOLOGicaldescriptionNon-selectiveproteinkinaseinhibitor(IC50valuesare10-30nMforserine/threonineproteinkinases).PKCandCa2+/calmodulin-stimulatedphosphodiesteraseinhibitor(IC50valuesare32.9nMand1.8-2.8µMrespectively).Competitivelyinhibitsmyosinlightchainkinase(MLCK)-mayinteractwiththeATP-bindingdomain(Ki=20nM).BlocksneuronaldifferentiationbypotentlyinhibitingNGFreceptorgp140trktyrosineproteinkinase(IC50=3nM).Cellpermeableandshowspotentialanti-tumoractions.
- BiologicalactionInhibitor
- Purity>97%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameSF2370
- MolecularWeight467.5
- Chemicalstructure
![K-252a [99533-80-9]](images/hellobio/201710/hb0351.png "K-252a [99533-80-9]")
- MolecularFormulaC27H21N3O5
- CASNumber99533-80-9
- PubChemidentifier11612445
- SMILESC[C@]12[C@@](CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
StoringandUsingYourProduct
- SolubilityoverviewsolubleinDMSO(1mg/ml)orDMF(1mg/ml)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforK-252a
K-252a,apotentinhibitorofproteinkinaseCfrommicrobialorigin.
KaseHetal(1986)JAntibiot(Tokyo)39(8):1059-65.PubMedID:3759657K-252a,anovelmicrobialproduct,inhibitssmoothmusclemyosinlightchainkinase.
NakanishiSetal(1988)JBiolChem263(13):6215-9.PubMedID:2966151K252aisaselectiveinhibitorofthetyrosineproteinkinaseactivityofthetrkfamilyofoncogenesandneurotrophinreceptors.
TapleyPetal(1992)Oncogene7(2):371-81.PubMedID:1312698TheeffectofK-252a,apotentmicrobialinhibitorofproteinkinase,onactivatedcyclicnucleotidephosphodiesterase.
MatsudaYetal(1988)BiochemJ256(1):75-80.PubMedID:2851986
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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