Hello Bio/(+)-JQ1/HB1448/10mg
商品编号:
HB1448-10mg
品牌:
hellobio
市场价:
¥2983.50
美元价:
2295.00
产品分类:
酸碱缓冲液
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Productoverview
- Name(+)-JQ1
- ShortdescriptionPotent,selective,competitiveBETbromodomaininhibitor
- BIOLOGicaldescriptionPotent,selectiveandcompetitiveBETbromodomaininhibitor(Kdvaluesare50and90nMforbindingto1stand2ndBRD4bromodomains;IC50valuesare77and33nMfor1stand2ndBRD4bromodomains).DisplacesBRD4fusiononcoproteinfromchromatininsquamouscarcinoma.Showsantiproliferativeactions.
- Alternativenames(+)-SGCBD01
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-aceticacid1,1-dimethylethylester
- MolecularWeight456.99
- Chemicalstructure
- MolecularFormulaC23H25ClN4O2S
- CASNumber1268524-70-4
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor(+)-JQ1
TherapeutictargetingofBETbromodomainproteinsincastration-resistantprostatecancer.
AsanganiIAetal(2014)Nature510(7504):278-82.PubMedID:24759320SelectiveinhibitionofBETbromodomains.
FilippakopoulosPetal(2010)Nature468(7327):1067-73.PubMedID:20871596InhibitionofBromodomainProteinsfortheTreatmentofHumanDiffuseLargeB-cellLymphoma.
TrabuccoSEetal(2015)ClinCancerRes21(1):113-22.PubMedID:25009295
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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