Hello Bio/JNJ 16259685/HB0348/50mg
商品编号：
HB0348-50mg
品牌：
hellobio
市场价：
¥6532.50
美元价：
5025.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameJNJ16259685
- ShortdescriptionPotent,selective,non-competitivemGlu1antagoNIST
- BIOLOGicaldescription
Potent,selectiveandnon-competitivemGlu1receptorantagonist(Ki=0.34nMatmGlu1a).
DisplaysnoactivityatmGlu2,mGlu3,mGlu4,mGlu6,NMDAorAMPAreceptors(IC50=>10μM). Blood-brainbarrierpermeable.
Inhibitsglutamate-inducedCa2+ mobilization(IC50 =3.24nMatrecombinantratmGlu1a receptor).
Decreasesdrugandalcoholaddictionbehavioursinrodents.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
- MolecularWeight325.41
- Chemicalstructure
![JNJ 16259685 [409345-29-5]](images/hellobio/201710/hb0348.png "JNJ 16259685 [409345-29-5]")
- MolecularFormulaC20H23NO3
- CASNumber409345-29-5
- PubChemidentifier11313361
- SMILESCOC1CCC(CC1)C(=O)C2=CC3=CC4=C(N=C3C=C2)OCCC4
- InChiInChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3
- InChiKeyQOTAQTRFJWLFCR-UHFFFAOYSA-N
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinethanol(100mM)andinDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforJNJ16259685
JNJ16259685,ahighlypotent,selectiveandsystemicallyactivemGlu1receptorantagonist.
LavreysenHetal(2004)Neuropharmacology47(7):961-72.PubMedID:15555631EffectsofmGluR1antagonisminthedorsalhippocampusondrugcontext-inducedreinstatementofcocaine-seekingbehaviorinrats.
XieXetal(2010)Psychopharmacology(Berl)208(1):1-11.PubMedID:19847405mGluR1withinthenucleusaccumbensregulatesalcoholintakeinmiceunderlimited-accessconditions.
LumENetal(2014)Neuropharmacology79:679-87.PubMedID:24467847Synthesis,structure-activityrelationship,andreceptorpharmacologyofanewseriesofquinolinederivativesactingasselective,noncompetitivemGlu1antagonists.
MABIreDetal(2005)JMedChem48(6):2134-53.PubMedID:15771457
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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