你好Bio/JNJ 16259685/HB0348/25mg
商品编号：
HB0348-25mg
品牌：
hellobio
市场价：
¥3978.00
美元价：
3060.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameJNJ 16259685
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Short descriptionPotent, selective, non-competitive mGlu1 antagonist
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Biological description
Potent, selective and non-competitive mGlu1 receptor antagonist (Ki = 0.34 nM at mGlu1a).
Displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, NMDA or AMPA receptors (IC50 = >10 μM). Blood-brain barrier permeable.
Inhibits glutamate-induced Ca2+ mobilization (IC50 = 3.24 nM at recombinant rat mGlu1a receptor).
Decreases drug and alcohol addiction behaviours in rodents.
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Biological actionAntagonist
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Purity>98%
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Properties
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Chemical name(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
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Molecular Weight325.41
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Chemical structure
![JNJ 16259685 [409345-29-5]](images/hellobio/201710/hb0348.png "JNJ 16259685 [409345-29-5]")
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Molecular FormulaC20H23NO3
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CAS Number409345-29-5
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PubChem identifier11313361
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SMILESCOC1CCC(CC1)C(=O)C2=CC3=CC4=C(N=C3C=C2)OCCC4
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InChiInChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3
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InChiKeyQOTAQTRFJWLFCR-UHFFFAOYSA-N
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in ethanol (100mM) and in DMSO (25mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for JNJ 16259685
JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.
Lavreysen H et al (2004) Neuropharmacology 47(7) : 961-72.PubMedID: 15555631Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.
Xie X et al (2010) Psychopharmacology (Berl) 208(1) : 1-11.PubMedID: 19847405mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.
Lum EN et al (2014) Neuropharmacology 79 : 679-87.PubMedID: 24467847Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
Mabire D et al (2005) J Med Chem 48(6) : 2134-53.PubMedID: 15771457
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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