Hello Bio/JNJ 10191584 maleate/HB1596/50mg
商品编号：
HB1596-50mg
品牌：
hellobio
市场价：
¥5557.50
美元价：
4275.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameJNJ10191584maleate
- ShortdescriptionPotent,selectiveH4receptorsilentantagoNIST
- BIOLOGicaldescriptionPotentandselectiveH4histaminereceptorsilentantagonist.SelectiveforhumanH4overH3by>540-fold(Kivaluesare26nMand14.1µMrespectively).Inhibitschemotaxisofmastcellsandeosinophilsinvitro.Showsanti-inflammatoryandantinociceptiveactions.
- AlternativenamesVUF6002
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazinemaleate
- MolecularWeight394.81
- Chemicalstructure
![JNJ 10191584 maleate [869497-75-6]](images/hellobio/201710/hb1596.png "JNJ 10191584 maleate [869497-75-6]")
- MolecularFormulaC13H15ClN4O.C4H4O4
- CASNumber869497-75-6
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- SolubilityoverviewsolubleinDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforJNJ10191584maleate
Synthesisandstructure-activityrelationshipsofindoleandbenzimidazolepiperazinesashistamineH(4)receptorantagonists.
TerziogluNetal(2004)BioorgMedChemLett14(21):5251-6.PubMedID:15454206InhibitoryeffectsofhistamineH4receptorantagonistsonexperimentalcolitisintherat.
VargaCetal(2005)EurJPharmacol522(1-3):130-8.PubMedID:16213481Preparationandbiologicalevaluationofindole,benzimidazole,andthienopyrrolepiperazinecarboxamides:potenthumanhistamineh(4)antagonists.
VenableJDetal(2005)JMedChem48(26):8289-98.PubMedID:16366610AntiinflammatoryandantinociceptiveeffectsoftheselectivehistamineH4-receptorantagonistsJNJ7777120andVUF6002inaratmodelofcarrageenan-inducedacuteinflammation.
CoruzziGetal(2007)EurJPharmacol563(1-3):240-4.PubMedID:17382315
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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