Product overview
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NameJF-NP-26 (Caged-Raseglurant)
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Short descriptionNovel, inactive photocaged derivative of raseglurant which can be uncaged with violet light. Shows light-dependent analgesic activity in vivo.
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Biological description
JF-NP-26 (Caged-Raseglurant) is a novel, inactive photocaged derivative of raseglurant (the mGlu5 receptor negative allosteric modulator (NAM)).
JF-NP-26 (Caged-Raseglurant) can be illuminated and uncaged by violet light (405 nM), to release raseglurant with spatial and temporal precision and allow local modulation of mGlu5 receptors. Unlike other caged compounds, JF-NP-26 can be uncaged by light within the visible spectrum which is advantageous for translation studies.
JF-NP-26 (Caged-Raseglurant) is active in vivo, can be administered systemically and activated by LED-based illumination to induce JF-NP-26-mediated, light-dependent analgesia in both neuropathic and acute/tonic inflammatory pain models. No liver toxicity was observed in JF-NP-26 treatments used in tested pain models. -
Biological actionNAM
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Purity>98%
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Properties
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Chemical name(7-(diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyidin-3-yl)carbamate
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Molecular Weight513.57
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Chemical structure
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Molecular FormulaC30H28FN3O4
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SourceSynthetic
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InChiKeyXBUISHYVUXKBCO-UHFFFAOYSA-N
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AppearanceYellow solid
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewSoluble in DMSO (100mM)
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HandlingThis compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References for JF-NP-26 (Caged-Raseglurant)
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.
Font et al (2017) ELife pii: e23545. : doi: 10.7554/eLife.23545.PubMedID: 28395733
