Hello Bio/JF-NP-26 (Caged-Raseglurant)/HB6127/1mg-免疫在线蚂蚁淘旗下平台

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商品详细Hello Bio/JF-NP-26 (Caged-Raseglurant)/HB6127/1mg

Hello Bio/JF-NP-26 (Caged-Raseglurant)/HB6127/1mg

商品编号： HB6127-1mg

品牌： hellobio

市场价： ¥897.00

美元价： 690.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Productoverview

Name
JF-NP-26(Caged-Raseglurant)
Shortdescription
Novel,inactivephotocagedderivativeofraseglurantwhichcanbeuncagedwithvioletlight.Showslight-dependentanalgesicactivityinvivo.
BIOLOGicaldescription
JF-NP-26(Caged-Raseglurant)isanovel,inactivephotocagedderivativeofraseglurant(themGlu5receptornegativeallostericmodulator(NAM)).

JF-NP-26(Caged-Raseglurant)canbeIlluminatedanduncagedbyvioletlight(405nM),toreleaseraseglurantwithspatialandtemporalprecisionandallowlocalmodulationofmGlu5receptors.Unlikeothercagedcompounds,JF-NP-26canbeuncagedbylightwithinthevisIBLespectrumwhichisadvantageousfortranslationstudies.

JF-NP-26(Caged-Raseglurant)isactiveinvivo,canbeadmiNISTeredsystemicallyandactivatedbyLED-basedilluminationtoinduceJF-NP-26-mediated,light-dependentanalgesiainbothneuropathicandacute/tonicinflammatorypainmodels.NolivertoxicitywasobservedinJF-NP-26treatmentsusedintestedpainmodels.
Biologicalaction
NAM
Purity
>98%
Ourproductsinaction
SubmitYourCitationNow

Properties

Chemicalname
(7-(diethylamino)-2-oxo-2H-chromen-4-yl)methyl(2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyidin-3-yl)carbamate
MolecularWeight
513.57
Chemicalstructure
MolecularFormula
C₃₀H₂₈FN₃O₄
Source
Synthetic
InChiKey
XBUISHYVUXKBCO-UHFFFAOYSA-N
Appearance
Yellowsolid

StoringandUsingYourProduct

Storageinstructions
-20°C
Solubilityoverview
SolubleinDMSO(100mM)
Handling
Thiscompoundislightsensitive;exposuretolightmayaffectcompoundperformance.Wethereforerecommendstoringthematerialinthedarkandprotectingfromlight.
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse

ReferencesforJF-NP-26(Caged-Raseglurant)

OpticalcontrolofpaininvivowithaphotoactivemGlu5receptornegativeallostericmodulator.
Fontetal(2017)ELifepii:e23545.:doi:10.7554/eLife.23545.
PubMedID:28395733

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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服务热线：4000-520-616

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