你好Bio/IWP 2/HB0344/25mg
商品编号：
HB0344-25mg
品牌：
hellobio
市场价：
¥3412.50
美元价：
2625.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIWP2
- ShortdescriptionPotentWntpathwayinhibitorandPORCNinhibitor.SuppressesR1ESCself-renewal.
- BIOLOGicaldescriptionPotentWntpathwayinhibitor(IC50=27nM)andPORCNinhibitor.AlsoinhibitsDishevelled-2(Dvl2-aWnt-Fzsignallingcomponent)andLRP5/6phosphorylationwithoutinducingaxinstABIlity.AlsosuppressesR1ESCself-renewal.Blocksphagocytosisandsecretionofpro-inflammatorycytokines.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
- MolecularWeight466.6
- Chemicalstructure
![IWP 2 [686770-61-6]](images/hellobio/201710/hb0344.png "IWP 2 [686770-61-6]")
- MolecularFormulaC22H18N4O2S3
- CASNumber686770-61-6
- PubChemidentifier2155128
- SMILESCC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(10mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIWP2
Wnt-frizzledsignalingispartofanFGF-inducedcascadethatpromoteslensfiberdifferentiation.
DawesLJetal(2013)InvestOphthalmolVisSci54(3):1582-90.PubMedID:23385791PorcupineisnotrequiredfortheproductionofthemajorityofWntsfromprimaryhumanastrocytesandCD8+Tcells.
RichardsMHetal(2014)PLoSOne9(3):e92159.PubMedID:24647048Smallmolecule-mediateddisruptionofWnt-dependentsignalingintissueregenerationandcancer.
ChenBetal(2009)NatChemBiol5(2):100-7.PubMedID:19125156
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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