Hello Bio/Isradipine/HB1223/10mg
商品编号：
HB1223-10mg
品牌：
hellobio
市场价：
¥799.50
美元价：
615.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIsrADIpine
- ShortdescriptionL-typevoltagegatedcalciumchannelblocker
- BIOLOGicaldescriptionL-typevoltagegatedcalciumchannelblocker(EC50=1.4nM).HighestaffinityforCav1.3andCav1.2channelsoverCav1.4.Displaysneuroprotectiveproperties.Bloodbrainbarrierpermeable.
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester
- MolecularWeight371.39
- Chemicalstructure
![Isradipine [75695-93-1]](images/hellobio/201710/hb1223.png "Isradipine [75695-93-1]")
- MolecularFormulaC19H21N3O5
- CASNumber75695-93-1
- PubChemidentifier3784
- SMILESCC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
- InChiInChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
- InChiKeyHMJIYCCIJYRONP-UHFFFAOYSA-N
- MDLnumberMFCD00153820
- AppearanceYellowsolid
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(50mM)orethanol(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIsradipine
TheL-typechannelantagoNISTisradipineisneuroprotectiveinamousemodelofParkinson"sdisease.
IlijicEetal(2011)NeurobiolDis43(2):364-71.PubMedID:21515375Expressionand1,4-dihydropyridine-bindingpropertiesofbrainL-typecalciumchannelisoforms.
Sinnegger-BraunsMJetal(2009)MolPharmacol75(2):407-14.PubMedID:19029287L-typevoltage-gatedcalciumchannelblockadewithisradipineasatherapeuticstrategyforAlzheimer"sdisease.
AnekondaTSetal(2011)NeurobiolDis41(1):62-70.PubMedID:20816785PN200-110,anewcalciumantagonist:electrophysiological,inotropic,andchronotropiceffectsonguineapigmyocardialtissueandeffectsoncontractionandcalciumuptakeofrabbitaorta.
HofRPetal(1984)JCardiovascPharmacol6(3):399-406.PubMedID:6202964
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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