你好生物/IOX 1/HB1409/25mg
商品编号：
HB1409-5mg
品牌：
hellobio
市场价：
¥1111.50
美元价：
855.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameIOX 1
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Short descriptionJMJD histone demethylase inhibitor
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Biological descriptionJMJD histone demethylase inhibitor. Inhibits JMJD2A, JMJD2E, PHD2 and FIH (IC50 values are 1.7, 2.4, 14.3 and 20.5 µM respectively). Cell permeable.
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Alternative names5-carboxy-8HQ; SID 85736331
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name8-Hydroxy-5-quinolinecarboxylic acid
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Molecular Weight189.17
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Chemical structure
![IOX 1 [5852-78-8]](images/hellobio/201710/hb1409.png "IOX 1 [5852-78-8]")
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Molecular FormulaC10H7NO3
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CAS Number5852-78-8
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in NaOH(aq) (100mM, 1eq. NaOH) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for IOX 1
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
King ON et al (2010) PLoS One 5(11) : e15535.PubMedID: 21124847A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.
Schiller R et al (2014) ChemMedChem 9(3) : 566-71.PubMedID: 24504543
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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