你好Bio/IOX 1/HB1409/5mg
商品编号：
HB1409-5mg
品牌：
hellobio
市场价：
¥1111.50
美元价：
855.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIOX1
- ShortdescriptionJMJDhistonedemethylaseinhibitor
- BIOLOGicaldescriptionJMJDhistonedemethylaseinhibitor.InhibitsJMJD2A,JMJD2E,PHD2andFIH(IC50valuesare1.7,2.4,14.3and20.5µMrespectively).Cellpermeable.
- Alternativenames5-carboxy-8HQ;SID85736331
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname8-Hydroxy-5-quinolinecarboxylicacid
- MolecularWeight189.17
- Chemicalstructure
![IOX 1 [5852-78-8]](images/hellobio/201710/hb1409.png "IOX 1 [5852-78-8]")
- MolecularFormulaC10H7NO3
- CASNumber5852-78-8
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinNaOH(aq)(100mM,1eq.NaOH)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIOX1
Quantitativehigh-throughputscreeningidentifies8-hydroxyquinolinesascell-activehistonedemethylaseinhibitors.
KingONetal(2010)PLoSOne5(11):e15535.PubMedID:21124847Acell-permeableesterderivativeoftheJmjChistonedemethylaseinhibitorIOX1.
SchillerRetal(2014)ChemMedChem9(3):566-71.PubMedID:24504543
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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