Hello Bio/Ifenprodil/HB0339/10mg
商品编号：
HB0339-10mg
品牌：
hellobio
市场价：
¥624.00
美元价：
480.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIfenprodil
- ShortdescriptionNon-competitiveGluN2BsubunitselectiveNMDARallostericinhibitor
- BIOLOGicaldescription
Non-competitive,voltage-independentGluN2BsubunitselectiveNMDAreceptorallostericinhibitor(IC50=0.15μM).
SelectiveoverGluN2A(NR2A),GluN2C(NR2C)andGluN2D(NR2D)subunits(IC50valuesare>30μM).
ThoughttobindattheinterfaceoftheGluN1/2BNTD(ATD)(N-terminaldomain).
IfenprodiliscommonlyusedtodistinguishbetweenGluN2B-andGluN2A-containingNMDARsinsynapticandextrasynapticmembranes.Alsoshowsusedependenceinwhichbindingofglutamateincreasesbindingofifenprodilandviceversa.
Showsneuroprotectiveeffects.Protectsneuronsagainstglutamateexcitotoxicityinanactivity-dependentmanner. - BiologicalactionAntagoNIST
- Purity>99%
- Ourproductsinaction1citationSubmitYourCitationNow
Properties
- Chemicalname(1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanolhemitartrate
- MolecularWeight400.49
- Chemicalstructure
![Ifenprodil [23210-58-4]](images/hellobio/201710/hb0339.png "Ifenprodil [23210-58-4]")
- MolecularFormulaC21H27NO2.½C4H6O6
- CASNumber23210-58-4
- PubChemidentifier656586
- SMILESCC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
- InChiInChI=1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h4*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
- InChiKeyDMPRDSPPYMZQBT-CEAXSRTFSA-N
- MDLnumberMFCD01529999
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(15mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIfenprodil
Ifenprodil,anovelNMDAreceptorantagonist:siteandmechanismofaction.
WilliamsK(2001)CurrDrugTargets2(3):285-98.PubMedID:11554553IfenprodilisanoveltypeofNMDAreceptorantagonist:interactionwithpolyamines.
ReynoldsIJetal(1989)MolPharmacol36(5):758-65.PubMedID:2555674Ageandactivationdeterminestheanticonvulsanteffectofifenprodilinrats.
MarešP(2014)NaunynSchmiedebergsArchPharmacol387(8):753-61.PubMedID:24807824IfenprodileffectsonGluN2B-containingglutamatereceptors.
Amico-RuvioSAetal(2012)MolPharmacol82(6):1074-81.PubMedID:22936815
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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