Hello Bio/IEM-1460/HB0338/10mg
商品编号：
HB0338-10mg
品牌：
hellobio
市场价：
¥916.50
美元价：
705.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIEM-1460
- ShortdescriptionCompetitive,selective,GluA2(GluR2)-lackingAMPAreceptorblocker
- BIOLOGicaldescription
Competitive,selective,voltage-dependentopen-channelCa2+permeableGluA2(GluR2)-lackingAMPAreceptorblocker(IC50valuesare2.6and1102µMatGluA2-lackingandGluA2-containingAMPARsrespectively).
IEM-1460canbeutilizedasanindicatorofthedistributionofAMPAreceptorsubtypesamongpopulationsofbraincells.IEM-1460canalsobeusedtoselectivelytargetGABAergicinterneurons,asseveralsubpopulationsoftheseneuronsexpressasignificantproportionofGluA2-lackingCa2+-permeableAMPARs.
Blockssynapticexcitationoffast-spikinginterneuronsandblocksNMDAR-mediatedcurrents.Alsoshowsanticonvulsantproperties.
- BiologicalactionBlocker
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN,N,N-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromidehydrobromide
- MolecularWeight454.33
- Chemicalstructure
![IEM-1460 [121034-89-7]](images/hellobio/201710/hb0338_1.png "IEM-1460 [121034-89-7]")
- MolecularFormulaC19H37BrN2.HBr
- CASNumber121034-89-7
- SMILES[Br-].Br.C[N+](C)(C)CCCCCNCC13CC2CC(CC(C1)C2)C3
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- Solubilityoverviewsolubleinwater(100mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIEM-1460
Theopenchannelblockingdrug,IEM-1460,revealsfunctionallydistinctalpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionatereceptorsinratbrainneurons.
Samoilovaetal(1999)Neuroscience94(1):261-8PubMedID:10613516CharacterizationofAMPAreceptorpopulationsinratbraincellsbytheuseofsubunit-specificopenchannelblockingdrug,IEM-1460.
Buldakovaetal(1999)BrainRes846(1):52-8PubMedID:10536213TwomechanismsofactionoftheadamantanederivativeIEM-1460athumanAMPA-typeglutamatereceptors.
Schlesingeretal(2005)BrJPharmacol145(5):656-63PubMedID:15834439Selectiveinhibitionofstriatalfast-spikinginterneuronscausesdyskinesias.
Gittisetal(2011)JNeurosci31(44):15727-31PubMedID:22049415
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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