Hello Bio/ICI 182,780 (Fulvestrant)/HB2501/50mg
商品编号：
HB2501-50mg
品牌：
hellobio
市场价：
¥2925.00
美元价：
2250.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameICI182,780(Fulvestrant)
- ShortdescriptionEstrogenreceptor(ER)antagoNISTandhighaffinityGPERagonist
- BIOLOGicaldescriptionEstrogenreceptor(ER)antagonist(Kivaluesare1and3.6nMatERαandERβrespectively).Showsnoagonistactivityandisdevoidofestrogenicactivity.AlsoahighaffinityagonistatGPER(GPR30).Down-regulatestheERandimpairsnuclearshuttlinganddimerizationofthereceptor.Showsanticanceractivity.Activeinvivo.
- AlternativenamesFulvestrant
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
- MolecularWeight606.77
- Chemicalstructure
- MolecularFormulaC32H47F5O3S
- CASNumber129453-61-8
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforICI182,780(Fulvestrant)
Emergingdataontheefficacyandsafetyoffulvestrant,auniqueantiestrogentherapyforadvancedbreastcancer.
ScottSMetal(2011)ExpertOpinDrugSaf10(5):819-26.PubMedID:21699443Antagonistsselectiveforestrogenreceptoralpha.
SunJetal(2002)Endocrinology143(3):941-7.PubMedID:11861516Estrogenanditsreceptorsincancer.
ChenGGetal(2008)MedResRev28(6):954-74.PubMedID:18642351ActivationofthehumanestrogenreceptorbytheantiestrogensICI182,780andtamoxifeninyeastgeneticsystems:implicationsfortheirmechanismofaction.
DudleyMWetal(2000)ProcNatlAcadSciUSA97(7):3696-701.PubMedID:10725345
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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