Hello Bio/ICG 001/HB0331/10mg
商品编号：
HB0331-10mg
品牌：
hellobio
市场价：
¥2203.50
美元价：
1695.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameICG001
- ShortdescriptionSelective,competitiveinhibitorofβ-catenin/CBPinteraction
- BIOLOGicaldescriptionSelectiveandcompetitiveinhibitorofβ-catenin/CREB-bindingprotein(CBP)interaction(IC50=3.0µM).Exhibitslittleactivityonβ-catenin/p300.AlsoinhibitsTGF-β1inducedα-SMAinduction.Displayscardioprotectiveandapoptosisinducingproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
- MolecularWeight548.63
- Chemicalstructure
![ICG 001 [847591-62-2]](images/hellobio/201710/hb0331.png "ICG 001 [847591-62-2]")
- MolecularFormulaC33H32N4O4
- CASNumber847591-62-2
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforICG001
ThesmallmoleculeWntsignalingmodulatorICG-001improvescontractilefunctioninchronicallyinfarctedratmyocardium.
SasakiTetal(2013)PLoSOne8(9):e75010.PubMedID:24069374ICG-001,anovelsmallmoleculeregulatorofTCF/beta-catenintranscription.
EguchiMetal(2005)MedChem1(5):467-72.PubMedID:16787331Asmallmoleculeinhibitorofbeta-catenin/CREB-bindingproteintranscription[corrected].
EmamiKHetal(2004)ProcNatlAcadSciUSA101(34):12682-7.PubMedID:15314234Interactionsbetweenβ-cateninandtransforminggrowthfactor-βsignalingpathwaysmediateepithelial-mesenchymaltransitionandaredependentonthetranscriptionalco-activatorcAMP-responseelement-bindingprotein(CREB)-bindingprotein(CBP)
ZhouBetal(2012)JBiolChem287(10):7026-38.PubMedID:22241478
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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