Hello Bio/I-BET 151 hydrochloride/HB1446/50mg
商品编号：
HB1446-50mg
品牌：
hellobio
市场价：
¥8950.50
美元价：
6885.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameI-BET151hydrochloride
- ShortdescriptionBETbromodomaininhibitor
- BIOLOGicaldescriptionBETbromodomaininhibitor.Inhibitscytokine-inducedtranscriptionofSTATtargetsanddownregulatescytokineproduction.Showsanti-inflammatoryandanti-canceractions.
- AlternativenamesI-BET151
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-onehydrochloride
- MolecularWeight451.9
- Chemicalstructure
- MolecularFormulaC23H21N5O3.HCl
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforI-BET151hydrochloride
TheBETBromodomainInhibitorI-BET151ActsDownstreamofSmoothenedProteintoAbrogatetheGrowthofHedgehogProtein-drivenCancers.
LongJetal(2014)JBiolChem289(51):35494-502.PubMedID:25355313BETbromodomaininhibitionsuppressestranscriptionalresponsestocytokine-Jak-STATsignalinginagene-specificmannerinhumanmonocytes.
ChanCHetal(2015)EurJImmunol45(1):287-97.PubMedID:25345375ControlofNF-kBactivityinhumanmelanomabybromodomainandextra-terminalproteininhibitorI-BET151.
GallagherSJetal(2014)PigmentCellMelanomaRes27(6):1126-37.PubMedID:24924589
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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