Hello Bio/10Z-Hymenialdisine/HB1264/1mg
商品编号：
HB1264-1mg
品牌：
hellobio
市场价：
¥6435.00
美元价：
4950.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name10Z-Hymenialdisine
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Short descriptionPan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
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Biological descriptionPan kinase inhibitor. Potently inhibits MEK1 (IC50 = 6 nM at MEK-1) and GSK-3β. Also Inhibits IL-8, CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDk3/cyclin E and CDK5/p35 (IC50 values are 0.41 µM, 22, 70, 40, 100 and 28 nM respectively). Exhibits reduced activity at CDK4/cyclin D1 and CDK6/cyclin D2 (IC50 values are 600 and 700 nM respectively). Displays growth inhibitory properties towards tumor cells.
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Biological actionInhibitor
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Purity>97%
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Properties
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Chemical name(4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4 H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropy rrolo[2,3-c]azepin-8(1H)-one
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Molecular Weight324.13
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Chemical structure
![10Z-Hymenialdisine [82005-12-7]](images/hellobio/201710/hb1264.png "10Z-Hymenialdisine [82005-12-7]")
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Molecular FormulaC11H10BrN5O2
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CAS Number82005-12-7
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewsoluble in DMSO (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for 10Z-Hymenialdisine
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Tasdemir D et al (2002) J Med Chem 45(2) : 529-32.PubMedID: 11784156Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Meijer L et al (2000) Chem Biol 7(1) : 51-63.PubMedID: 10662688
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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