Hello Bio/10Z-Hymenialdisine/HB1264/250μg
商品编号：
HB1264-250μg
品牌：
hellobio
市场价：
¥1911.00
美元价：
1470.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name10Z-Hymenialdisine
- ShortdescriptionPankinaseinhibitor.PotentlyinhibitsMEK1,Cdk1,Cdk2,Cdk3andCdk5andGSK-3β.
- BIOLOGicaldescriptionPankinaseinhibitor.PotentlyinhibitsMEK1(IC50=6nMatMEK-1)andGSK-3β.AlsoInhibitsIL-8,CDK1/cyclinB,CDK2/cyclinA,CDK2/cyclinE,CDk3/cyclinEandCDK5/p35(IC50valuesare0.41µM,22,70,40,100and28nMrespectively).ExhibitsreducedactivityatCDK4/cyclinD1andCDK6/cyclinD2(IC50valuesare600and700nMrespectively).Displaysgrowthinhibitorypropertiestowardstumorcells.
- BiologicalactionInhibitor
- Purity>97%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
- MolecularWeight324.13
- Chemicalstructure
![10Z-Hymenialdisine [82005-12-7]](images/hellobio/201710/hb1264.png "10Z-Hymenialdisine [82005-12-7]")
- MolecularFormulaC11H10BrN5O2
- CASNumber82005-12-7
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor10Z-Hymenialdisine
AldisinealkaloidsfromthePhilippinespongeStylissamassaarepotentinhibitorsofmitogen-activatedproteinkinasekinase-1(MEK-1).
TasdemirDetal(2002)JMedChem45(2):529-32.PubMedID:11784156Inhibitionofcyclin-dependentkinases,GSK-3betaandCK1byhymenialdisine,amarinespongeconstituent.
MeijerLetal(2000)ChemBiol7(1):51-63.PubMedID:10662688
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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