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Hello Bio/1,2,3,4,5,6-Hexabromocyclohexane/HB1428/50mg
Hello Bio/1,2,3,4,5,6-Hexabromocyclohexane/HB1428/50mg
商品编号：
HB1428-50mg
品牌：
hellobio
市场价：
¥1287.00
美元价：
990.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name1,2,3,4,5,6-Hexabromocyclohexane
- ShortdescriptionPotent,selectiveJAK2inhibitor
- BIOLOGicaldescriptionPotentandselectiveJAK2tyrosinekinaseinhibitor,inhibitsautophosphorylationofJAK2.Showsapoptoticactions
- AlternativenamesHex;HBC;NSC7908
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1,2,3,4,5,6-Hexabromocyclohexane
- MolecularWeight557.54
- Chemicalstructure
![1,2,3,4,5,6-Hexabromocyclohexane [1837-91-8]](images/hellobio/201710/hb1428.png "1,2,3,4,5,6-Hexabromocyclohexane [1837-91-8]")
- MolecularFormulaC6H6Br6
- CASNumber1837-91-8
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(10mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor1,2,3,4,5,6-Hexabromocyclohexane
Identificationof1,2,3,4,5,6-hexabromocyclohexaneasasmallmoleculeinhibitorofjak2tyrosinekinaseautophosphorylation[correctionofautophophorylation].
SandbergEMetal(2005)JMedChem48(7):2526-33.PubMedID:15801842Growthhormone-stimulatedinsulin-likegrowthfactor-1expressioninrainbowtrout(Oncorhynchusmykiss)hepatocytesismediatedbyERK,PI3K-AKT,andJAK-STAT.
ReindlKMetal(2011)AmJPhysiolRegulIntegrCompPhysiol301(1):R236-43.PubMedID:21490369Jak2inhibitiondeactivatesLynkinasethroughtheSET-PP2A-SHP1pathway,causingapoptosisindrug-resistantcellsfromchronicmyelogenousleukemiapatients.
SamantaAKetal(2009)Oncogene28(14):1669-81.PubMedID:19234487
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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