Hello Bio/H 89 dihydrochloride/HB0314/50mg
商品编号：
HB0314-50mg
品牌：
hellobio
市场价：
¥7195.50
美元价：
5535.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameH 89 dihydrochloride
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Short descriptionPotent, non-selective kinase inhibitor
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Biological descriptionPotent, non-selective kinase inhibitor. Protein kinase A inhibitor (IC50 = 135 nM). Also inhibits S6K1, MSK1, ROCKII, PKBα and MAPKAP-Klb (IC50 values are 80, 120 and 270 nM, 2.6 µM and 2.8 µM respectively).
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameN-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride
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Molecular Weight519.28
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Chemical structure
![H 89 dihydrochloride [130964-39-5]](images/hellobio/201710/hb0314.png "H 89 dihydrochloride [130964-39-5]")
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Molecular FormulaC20H20BrN3O2S.2HCl
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CAS Number130964-39-5
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewsoluble in water (25mM) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for H 89 dihydrochloride
The many faces of H89: a review.
Lochner A et al (2006) Cardiovasc Drug Rev 24(3-4) : 261-74.PubMedID: 17214602Involvement of cAMP response element-binding protein activation in salivary secretion.
Yamada K et al (2006) Pathobiology 73(1) : 1-7.PubMedID: 16785762Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.PubMedID: 10998351Pharmacological PKA inhibition: all may not be what it seems.
Murray AJ (2008) Sci Signal 1(22) : re4.PubMedID: 18523239
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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