Hello Bio/H 89 dihydrochloride/HB0314/10mg
商品编号：
HB0314-10mg
品牌：
hellobio
市场价：
¥1774.50
美元价：
1365.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameH89dihydrochloride
- ShortdescriptionPotent,non-selectivekinaseinhibitor
- BIOLOGicaldescriptionPotent,non-selectivekinaseinhibitor.ProteinkinaseAinhibitor(IC50=135nM).AlsoinhibitsS6K1,MSK1,ROCKII,PKBαandMAPKAP-Klb(IC50valuesare80,120and270nM,2.6µMand2.8µMrespectively).
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride
- MolecularWeight519.28
- Chemicalstructure
![H 89 dihydrochloride [130964-39-5]](images/hellobio/201710/hb0314.png "H 89 dihydrochloride [130964-39-5]")
- MolecularFormulaC20H20BrN3O2S.2HCl
- CASNumber130964-39-5
StoringandUsingYourProduct
- Storageinstructions-20°C
- Solubilityoverviewsolubleinwater(25mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforH89dihydrochloride
ThemanyfacesofH89:areview.
LochnerAetal(2006)CardiovascDrugRev24(3-4):261-74.PubMedID:17214602InvolvementofcAMPresponseelement-bindingproteinactivationinsalivarysecretion.
YamadaKetal(2006)Pathobiology73(1):1-7.PubMedID:16785762Specificityandmechanismofactionofsomecommonlyusedproteinkinaseinhibitors.
DaviesSPetal(2000)BiochemJ351(Pt1):95-105.PubMedID:10998351PharmacologicalPKAinhibition:allmaynotbewhatitseems.
MurrayAJ(2008)SciSignal1(22):re4.PubMedID:18523239
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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