Hello Bio/H-8/HB0318/25mg
商品编号：
HB0318-5mg
品牌：
hellobio
市场价：
¥1345.50
美元价：
1035.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameH-8
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Short descriptionPKA / PKG inhibitor
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Biological descriptionPKG (cGPK), PKA, PKC, Myosin light chain kinase (MLCK), Casein kinase (CK) 1 and 2 inhibitor (Ki values are 0.48, 1.2, 15, 68, 133 and 950 µM respectively). Blocks cell cycle progression.
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameN-[2-(methylamino)ethyl]isoquinoline-5-sulfonamidedihydrochloride
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Molecular Weight338.25
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Chemical structure
![H-8 [84478-11-5]](images/hellobio/201710/hb0318.png "H-8 [84478-11-5]")
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Molecular FormulaC12H15N3O2S.2HCl
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CAS Number84478-11-5
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PubChem identifier150584
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SMILESCNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2.Cl.Cl
Storing and Using Your Product
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Solubility overviewsoluble in DMSO (25mg/ml) or ethanol:water (25mg/ml, ratio 1:1)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for H-8
Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.
Ido M et al (1991) Br J Cancer 64(6) : 1103-7.PubMedID: 1684908Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
Hidaka H et al (1984) Biochemistry 23(21) : 5036-41.PubMedID: 6238627Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.
Ido M et al (1991) Br J Cancer 64(6) : 1103-7.PubMedID: 1684908
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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