Hello Bio/H-8/HB0318/5mg
商品编号：
HB0318-5mg
品牌：
hellobio
市场价：
¥1345.50
美元价：
1035.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameH-8
- ShortdescriptionPKA/PKGinhibitor
- BIOLOGicaldescriptionPKG(cGPK),PKA,PKC,Myosinlightchainkinase(MLCK),Caseinkinase(CK)1and2inhibitor(Kivaluesare0.48,1.2,15,68,133and950µMrespectively).Blockscellcycleprogression.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[2-(methylamino)ethyl]isoquinoline-5-sulfonamidedihydrochloride
- MolecularWeight338.25
- Chemicalstructure
![H-8 [84478-11-5]](images/hellobio/201710/hb0318.png "H-8 [84478-11-5]")
- MolecularFormulaC12H15N3O2S.2HCl
- CASNumber84478-11-5
- PubChemidentifier150584
- SMILESCNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2.Cl.Cl
StoringandUsingYourProduct
- SolubilityoverviewsolubleinDMSO(25mg/ml)orethanol:water(25mg/ml,ratio1:1)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforH-8
DifferentialgrowthinhibitionofisoquinolinesulfonamidesH-8andH-7towardsmultidrug-resistantP388murineleukaemiacells.
IdoMetal(1991)BrJCancer64(6):1103-7.PubMedID:1684908Isoquinolinesulfonamides,novelandpotentinhibitorsofcyclicnucleotidedependentproteinkinaseandproteinkinaseC.
HidakaHetal(1984)Biochemistry23(21):5036-41.PubMedID:6238627DifferentialgrowthinhibitionofisoquinolinesulfonamidesH-8andH-7towardsmultidrug-resistantP388murineleukaemiacells.
IdoMetal(1991)BrJCancer64(6):1103-7.PubMedID:1684908
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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