Hello Bio/GYKI 52466 hydrochloride/HB0311/10mg
商品编号：
HB0311-10mg
品牌：
hellobio
市场价：
¥1462.50
美元价：
1125.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameGYKI52466hydrochloride
- ShortdescriptionSelective,non-competitiveAMPAreceptorantagoNIST
- BIOLOGicaldescriptionSelective,non-competitiveAMPAreceptorantagonist(IC50valuesare11and7.5µMforAMPAandkainatereceptorsrespectively).InactiveatNMDAreceptors.Showsanti-convulsantandneuroprotectiveactions.
- AlternativenamesGYKI-52466
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenaminehydrochloride
- MolecularWeight329.79
- Chemicalstructure
![GYKI 52466 [102771-26-6]](images/hellobio/201710/hb0311.png "GYKI 52466 [102771-26-6]")
- MolecularFormulaC17H15N3O2.HCl
- CASNumber102771-26-6
- PubChemidentifier10042240
- SMILESCl.Nc1ccc(cc1)C3=NN=C(C)Cc2cc4OCOc4cc23
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- Storagebufferroomtemperature(desiccate)
- Solubilityoverviewsolubleinwater(10mM)orDMSO(25mM,heating)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforGYKI52466hydrochloride
GYKI52466,a2,3-benzodiazepine,isahighlyselective,noncompetitiveantagonistofAMPA/kainatereceptorresponses.
DonevanSDetal(1993)Neuron10(1):51-9.PubMedID:7678966PharmacologicalPreconditioningwithGYKI52466:AProphylacticApproachtoNeuroprotection.
GoultonCSetal(2010)FrontNeurosci4:PubMedID:20953290Comparisonofanticonvulsiveandacuteneuroprotectiveactivityofthree2,3-benzodiazepinecompounds,GYKI52466,GYKI53405,andGYKI53655.
SzabadosTetal(2001)BrainResBull55(3):387-91.PubMedID:11489346
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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