Hello Bio/GSK J4/HB1407/10mg
商品编号：
HB1407-10mg
品牌：
hellobio
市场价：
¥2028.00
美元价：
1560.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameGSKJ4
- ShortdescriptionJMJD3/UTXHistonedemethylaseinhibitor
- BIOLOGicaldescriptionJMJD3andUTXhistonedemethylaseinhibitor,GSKJ1prodrug.Cellpermeable.Reducesmacrophageproinflammatorycytokineproduction.ImprovessurvivalinCardio-facio-cutaneous(CFC)syndromeinmiceandinhibitsgrowthofT-cellacutelymphoblasticleukaemiacancercells.
- AlternativenamesGSK-J4;GSKJ4
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanineethylester
- MolecularWeight417.5
- Chemicalstructure
![GSK J4 [1373423-53-0]](images/hellobio/201710/hb1407.png "GSK J4 [1373423-53-0]")
- MolecularFormulaC24H27N5O2
- CASNumber1373423-53-0
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforGSKJ4
AselectivejumonjiH3K27demethylaseinhibitormodulatestheproinflammatorymacrophageresponse.
KruidenierLetal(2012)Nature488(7411):404-8.PubMedID:22842901NewBRAFknockinmiceprovideapathogeneticmechanismofdevelopmentaldefectsandatherapeuticapproachincardio-facio-cutaneoussyndrome.
InoueSetal(2014)HumMolGenet23(24):6553-66.PubMedID:25035421Contrastingrolesofhistone3lysine27demethylasesinacutelymphoblasticleukaemia.
NtziachristosPetal(2014)Nature514(7523):513-7.PubMedID:25132549
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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