Hello Bio/Go 6983/HB0303/10mg
商品编号：
HB0303-10mg
品牌：
hellobio
市场价：
¥2164.50
美元价：
1665.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameGo 6983
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Short descriptionBroad spectrum PKC inhibitor
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Biological descriptionBroad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 nM and 20 µM for PKC-α, PKC-β, PKC-γ, PKC-δ, PKC-ζ and PKC-µ respectively). Also suppresses TNF-α production (IC50 = 8.3 nM) and up-regulates Akt phosphorylation. Displays cardioprotective properties.
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
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Molecular Weight442.51
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Chemical structure
![Go 6983 [133053-19-7]](images/hellobio/201710/hb0303.png "Go 6983 [133053-19-7]")
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Molecular FormulaC26H26N4O3
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CAS Number133053-19-7
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PubChem identifier3499
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SMILESCN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
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InChiInChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
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InChiKeyLLJJDLHGZUOMQP-UHFFFAOYSA-N
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MDL numberMFCD04040031
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewSoluble in DMSO (50mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Go 6983
Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.
Young LH et al (2005) Cardiovasc Drug Rev 23(3) : 255-72.PubMedID: 16252018Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.
Foey AD et al (2004) Immunology 112(1) : 44-53.PubMedID: 15096183Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
Gschwendt M et al (1996) FEBS Lett 392(2) : 77-80.PubMedID: 8772178PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.
Kim SY et al (2011) BMB Rep 44(2) : 140-5.PubMedID: 21345315
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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