你好Bio/Go 6983/HB0303/1mg
商品编号：
HB0303-1mg
品牌：
hellobio
市场价：
¥429.00
美元价：
330.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameGo6983
- ShortdescriptionBroadspectrumPKCinhibitor
- BIOLOGicaldescriptionBroadspectrumproteinkinaseC(PKC)inhibitor(IC50valuesare7,7,6,10,60nMand20µMforPKC-α,PKC-β,PKC-γ,PKC-δ,PKC-ζandPKC-µrespectively).AlsosuppressesTNF-αproduction(IC50=8.3nM)andup-regulatesAktphosphorylation.Displayscardioprotectiveproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
- MolecularWeight442.51
- Chemicalstructure
![Go 6983 [133053-19-7]](images/hellobio/201710/hb0303.png "Go 6983 [133053-19-7]")
- MolecularFormulaC26H26N4O3
- CASNumber133053-19-7
- PubChemidentifier3499
- SMILESCN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
- InChiInChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
- InChiKeyLLJJDLHGZUOMQP-UHFFFAOYSA-N
- MDLnumberMFCD04040031
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewSolubleinDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforGo6983
Gö6983:afastactingproteinkinaseCinhibitorthatattenuatesmyocardialischemia/reperfusioninjury.
YoungLHetal(2005)CardiovascDrugRev23(3):255-72.PubMedID:16252018ConventionalproteinkinaseCandatypicalproteinkinaseCzetadifferentiallyregulatemacrophageproductionoftumournecrosisfactor-alphaandinterleukin-10.
FoeyADetal(2004)Immunology112(1):44-53.PubMedID:15096183InhibitionofproteinkinaseCmubyvariousinhibitors.Differentiationfromproteinkinasecisoenzymes.
GschwendtMetal(1996)FEBSLett392(2):77-80.PubMedID:8772178PKCinhibitorsRO31-8220andGö6983enhanceepinephrine-inducedplateletaggregationincatecholaminehypo-responsiveplateletsbyenhancingAktphosphorylation.
KimSYetal(2011)BMBRep44(2):140-5.PubMedID:21345315
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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