Hello Bio/Go 6976/HB0302/1mg
商品编号：
HB0302-1mg
品牌：
hellobio
市场价：
¥2028.00
美元价：
1560.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameGo6976
- ShortdescriptionPotent,selectivePKCinhibitor
- BIOLOGicaldescriptionPotentandselectiveproteinkinaseC(PKC)inhibitoratαandβ1subunits(IC50valuesare2.3and6.2nMrespectively).Displaysnoactivityatε,δ,andζPKCsubunits.AlsoaproteinkinaseD(IC50=20nM),JAK2,FLT3,TrkBandTrkAtyrosinekinasesinhibitor.Displaysantitumorproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
- MolecularWeight378.43
- Chemicalstructure
![Go 6976 [136194-77-9]](images/hellobio/201710/hb0302.png "Go 6976 [136194-77-9]")
- MolecularFormulaC24H18N4O
- CASNumber136194-77-9
- PubChemidentifier3501
- SMILESCN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforGo6976
Gö6976isapotentinhibitorofneurotrophin-receptorintrinsictyrosinekinase.
BehrensMMetal(1999)JNeuRochem72(3):919-24.PubMedID:10037462Gö6976isapotentinhibitoroftheJAK2andFLT3tyrosinekinaseswithsignificantactivityinprimaryacutemyeloidleukaemiacells.
GrandageVLetal(2006)BrJHaematol135(3):303-16.PubMedID:16956345SelectiveinhibitionofproteinkinaseCisozymesbytheindolocarbazoleGö6976.
Martiny-BaronGetal(1993)JBiolChem268(13):9194-7.PubMedID:8486620PutativeconventionalproteinkinaseCinhibitorGödecke6976[12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole]stimulatestransglutaminaseactivityinprimarymouseepidermalkeratinocytes.
ShapiroBAetal(2002)JPharmacolExpTher302(1):352-8.PubMedID:12065737
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
