Hello Bio/GBR 12909 dihydrochloride/HB1812/50mg
商品编号：
HB1812-50mg
品牌：
hellobio
市场价：
¥3334.50
美元价：
2565.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameGBR12909dihydrochloride
- ShortdescriptionPotent,competitivedopamineuptakeinhibitor
- BIOLOGicaldescriptionPotent,competitivedopamineuptakeinhibitor(Ki=1nM).AlsoapotentKv11.1,andNa+andCa+channelblocker(IC50valuesare0.8,320and830nMathKv11.1,hICa,LandhNav1.5respectivelyandσreceptorblocker).Showsvarietyofbiologicalactions.Activeinvivo.
- AlternativenamesVanoxerine
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazinedihydrochloride
- MolecularWeight523.49
- Chemicalstructure
![GBR 12909 dihydrochloride [67469-78-7]](images/hellobio/201710/hb1812.png "GBR 12909 dihydrochloride [67469-78-7]")
- MolecularFormulaC28H32F2N2O.2HCl
- CASNumber67469-78-7
- PubChemidentifier104920
- SMILESC1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
- InChiInChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
- InChiKeyMIBSKSYCRFWIRU-UHFFFAOYSA-N
- MDLnumberMFCD00055193
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(25mM,gentlewarming)andinDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforGBR12909dihydrochloride
ThedopamineinhibitorGBR12909:selectivityandmolecularmechanismofaction.
AndersenPH(1989)EurJPharmacol166(3):493-504.PubMedID:2530094Short-actingcocaineandlong-actingGBR-12909bothelicitrapiddopamineuptakeinhibitionfollowingintravenousdelivery.
Espaã±aRAetal(2008)Neuroscience155(1):250-7.PubMedID:18597947Vanoxerine:cellularmechanismofanewantiarrhythmic.
LacerdaAEetal(2010)JCardiovascElectrophysiol21(3):301-10.PubMedID:19817928
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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