Hello Bio/GBR 12909 dihydrochloride/HB1812/10mg
商品编号：
HB1812-10mg
品牌：
hellobio
市场价：
¥955.50
美元价：
735.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameGBR 12909 dihydrochloride
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Short descriptionPotent, competitive dopamine uptake inhibitor
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Biological descriptionPotent, competitive dopamine uptake inhibitor (Ki = 1 nM). Also a potent Kv11.1, and Na+ and Ca+ channel blocker (IC50 values are 0.8, 320 and 830 nM at hKv11.1, hICa,L and hNav1.5 respectively and σ receptor blocker). Shows variety of biological actions. Active in vivo.
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Alternative namesVanoxerine
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
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Molecular Weight523.49
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Chemical structure
![GBR 12909 dihydrochloride [67469-78-7]](images/hellobio/201710/hb1812.png "GBR 12909 dihydrochloride [67469-78-7]")
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Molecular FormulaC28H32F2N2O.2HCl
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CAS Number67469-78-7
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PubChem identifier104920
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SMILESC1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
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InChiInChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
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InChiKeyMIBSKSYCRFWIRU-UHFFFAOYSA-N
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MDL numberMFCD00055193
Storing and Using Your Product
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Storage instructionsRoom temperature (desiccate)
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Solubility overviewSoluble in water (25 mM, gentle warming) and in DMSO (50 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for GBR 12909 dihydrochloride
The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.
Andersen PH (1989) Eur J Pharmacol 166(3) : 493-504.PubMedID: 2530094Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery.
Espaã±a RA et al (2008) Neuroscience 155(1) : 250-7.PubMedID: 18597947Vanoxerine: cellular mechanism of a new antiarrhythmic.
Lacerda AE et al (2010) J Cardiovasc Electrophysiol 21(3) : 301-10.PubMedID: 19817928
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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