Hello Bio/Gabapentin/HB0857/
市场价：
¥1345.50
美元价：
1035.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameGabapentin
- ShortdescriptionGlutamatereleaseinhibitor/VSCCmodulator
- BIOLOGicaldescriptionK+-evokedglutamatereleaseinhibitor.Thoughttointeractwiththevoltage-sensitiveCa2+channel(VSCC),bindingattheα2δsubunit.InhibitsK+-inducedcytosolicCa2+increase(IC50=14µM).IncreasestheexpressionofIl-10anddecreasespro-inflammatorycytokinestoshowactionsagainstneuropathicpain.Alsoshowsanticonvulsant,analgesicandanti-epilepticactions.
- AlternativenamesGBP|Neurontin
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-(Aminomethyl)cyclohexaneaceticacid
- MolecularWeight171.24
- Chemicalstructure
![Gabapentin [60142-96-3]](images/hellobio/201710/hb0857.png "Gabapentin [60142-96-3]")
- MolecularFormulaC9H17NO2
- CASNumber60142-96-3
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- Solubilityoverviewsolubleinwater(100mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforGabapentin
Intrathecalgabapentinincreasesinterleukin-10expressionandinhibitspro-inflammatorycytokineinaratmodelofneuropathicpain.
LeeBSetal(2013)JKoreanMedSci28(2):308-14.PubMedID:23399960Amperometricmeasurementofglutamatereleasemodulationbygabapentinandpregabalininratneocorticalslices:roleofvoltage-sensitiveCa2+α2δ-1subunit.
QuinteroJEetal(2011)JPharmacolExpTher338(1):240-5.PubMedID:21464332InhibitionofneuronalCa(2+)influxbygabapentinandsubsequentreductionofneurotransmitterreleasefromratneocorticalslices.
FinkKetal(2000)BrJPharmacol130(4):900-6.PubMedID:10864898
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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