Hello Bio/Gabapentin/HB0857/50mg
商品编号：
HB0857-50mg
品牌：
hellobio
市场价：
¥3295.50
美元价：
2535.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
-
NameGabapentin
-
Short descriptionGlutamate release inhibitor / VSCC modulator
-
Biological descriptionK+-evoked glutamate release inhibitor. Thought to interact with the voltage-sensitive Ca2+ channel (VSCC), binding at the α2δ subunit. Inhibits K+-induced cytosolic Ca2+ increase (IC50 = 14 µM). Increases the expression of Il-10 and decreases pro-inflammatory cytokines to show actions against neuropathic pain. Also shows anticonvulsant, analgesic and anti-epileptic actions.
-
Alternative namesGBP | Neurontin
-
Biological actionInhibitor
-
Purity>99%
-
Our products in actionSubmit Your Citation Now
Properties
-
Chemical name1-(Aminomethyl)cyclohexaneacetic acid
-
Molecular Weight171.24
-
Chemical structure
![Gabapentin [60142-96-3]](images/hellobio/201710/hb0857.png "Gabapentin [60142-96-3]")
-
Molecular FormulaC9H17NO2
-
CAS Number60142-96-3
Storing and Using Your Product
-
Storage instructions+4°C (desiccate)
-
Solubility overviewsoluble in water (100mM, gentle warming)
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Gabapentin
Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain.
Lee BS et al (2013) J Korean Med Sci 28(2) : 308-14.PubMedID: 23399960Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ α2δ-1 subunit.
Quintero JE et al (2011) J Pharmacol Exp Ther 338(1) : 240-5.PubMedID: 21464332Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices.
Fink K et al (2000) Br J Pharmacol 130(4) : 900-6.PubMedID: 10864898
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
