Hello Bio/Fostriecin sodium salt/HB0293/50μg
商品编号：
HB0293-50μg
品牌：
hellobio
市场价：
¥2554.50
美元价：
1965.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameFostriecin sodium salt
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Short descriptionPotent protein phosphatase inhibitor
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Biological descriptionPotent protein phosphatase inhibitor. Inhibits PP4, PP2A, PP5C and PP1 (IC50 values are 3, 3.2 nM, 60 and 131 µM). Shows antibiotic and antitumor actions
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z ,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
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Molecular Weight452.37
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Chemical structure
![Fostriecin sodium salt [87860-39-7]](images/hellobio/201710/hb0293.png "Fostriecin sodium salt [87860-39-7]")
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Molecular FormulaC19H26O9PNa
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CAS Number87860-39-7
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PubChem identifier73324802
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SMILESCC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
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InChiInChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h4-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1
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InChiKeyXBUIKNRVGYFSHL-UHFFFAOYSA-M
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MDL numberMFCD09971059
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewSoluble in water (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Fostriecin sodium salt
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.
Walsh AH et al (1997) FEBS Lett 416(3) : 230-4.PubMedID: 9373158Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.
Hastie CJ et al (1998) FEBS Lett 431(3) : 357-61.PubMedID: 9714542Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.
Theobald B et al (2013) Mol Cancer Res 11(8) : 845-55.PubMedID: 23671329
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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