Hello Bio/Flumazenil/HB0915/100mg
商品编号：
HB0915-100mg
品牌：
hellobio
市场价：
¥7449.00
美元价：
5730.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameFlumazenil
- ShortdescriptionGABAAreceptorantagoNIST
- BIOLOGicaldescriptionGABAAreceptorantagonist,non-selectiveforα1,α2,α3orα5subunits.Bindsatthebenzodiazepinesite.Usedasareversalagentforbenzodiazepines.Reversestolerancetobenzodiazepinesandrestorestheneuroprotectiveactionsofdiazepaminischemiamodels.
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid,ethylester
- MolecularWeight303.29
- Chemicalstructure
![Flumazenil [78755-81-4]](images/hellobio/201710/hb0915.png "Flumazenil [78755-81-4]")
- MolecularFormulaC15H14FN3O3
- CASNumber78755-81-4
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewsolubleinDMSO(25mM,gentlewarming)orethanol(5mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforFlumazenil
Regionaldifferencesintheinhibitionofmouseinvivo[3H]Ro15-1788bindingreflectselectivityforalpha1versusalpha2andalpha3subunit-containingGABAAreceptors.
AtackJRetal(1999)Neuropsychopharmacology20(3):255-62.PubMedID:10063485Effectsofdiazepamandflumazenilonforebrainischaemiainaratmodelofbenzodiazepinetolerance.
IwataMetal(2012)BrJAnaesth109(6):935-42.PubMedID:23043146Rapidandreliablesedationinducedbydiazepamandantagonizedbyflumazenilinzebrafinches(Taeniopygiaguttata).
PratherJF(2012)JAvianMedSurg26(2):76-84.PubMedID:22872979
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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