Hello Bio/Flumazenil/HB0915/20mg
商品编号：
HB0915-20mg
品牌：
hellobio
市场价：
¥1872.00
美元价：
1440.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameFlumazenil
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Short descriptionGABAA receptor antagonist
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Biological descriptionGABAA receptor antagonist, non-selective for α1, α2, α3 or α5 subunits. Binds at the benzodiazepine site. Used as a reversal agent for benzodiazepines. Reverses tolerance to benzodiazepines and restores the neuroprotective actions of diazepam in ischemia models.
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Biological actionAntagonist
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Purity>99%
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Properties
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Chemical name8-Fluoro-5,6-dihydro-5-methyl-6-oxo -4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
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Molecular Weight303.29
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Chemical structure
![Flumazenil [78755-81-4]](images/hellobio/201710/hb0915.png "Flumazenil [78755-81-4]")
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Molecular FormulaC15H14FN3O3
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CAS Number78755-81-4
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewsoluble in DMSO (25mM, gentle warming) or ethanol (5mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Flumazenil
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.
Atack JR et al (1999) Neuropsychopharmacology 20(3) : 255-62.PubMedID: 10063485Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Iwata M et al (2012) Br J Anaesth 109(6) : 935-42.PubMedID: 23043146Rapid and reliable sedation induced by diazepam and antagonized by flumazenil in zebra finches (Taeniopygia guttata).
Prather JF (2012) J Avian Med Surg 26(2) : 76-84.PubMedID: 22872979
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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