Hello Bio/FK 506/HB0289/50mg
商品编号：
HB0289-50mg
品牌：
hellobio
市场价：
¥5109.00
美元价：
3930.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameFK506
- ShortdescriptionPotentcalcineurinphosphatase2Binhibitor
- BIOLOGicaldescriptionPotentcalcineurinphosphatase2B(PP2B)inhibitor(IC50=2nM).InteractswithFK-506bindingprotein.AlsoinhibitsIL-2productionbyactivatedT-cellsandreducesamountofGLUT4onhumanADIpocytes.Displaysneuroprotective,antibioticandimmunosuppressantproperties.
- AlternativenamesTacrolimus;Fujimycin;FK-506
- BiologicalactionAntibiotic
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
- MolecularWeight804.02
- MolecularFormulaC44H69NO12.H2O
- CASNumber104987-11-3
- PubChemidentifier445643
- SMILESC[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
- InChiInChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/
- InChiKeyQJJXYPPXXYFBGM-NYOQZLQMSA-N
- MDLnumberMFCD11045918
- AppearanceWhitetooff-white
StoringandUsingYourProduct
- Storageinstructions-20°C;
- SolubilityoverviewSolubleinethanol(100mM)andDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforFK506
PossIBLenitricoxidemodulationinprotectiveeffectofFK-506against3-nitropropionicacid-inducedbehavioral,oxidative,neuRochemical,andmitochondrialalterationsinratbrain.
KumarPetal(2010)DrugChemToxicol33(4):377-92.PubMedID:20550427ThecomplexofFK506-bindingprotein12andFK506inhibitscalcineurinphosphataseactivityandIgEactivation-inducedcytokinetranscripts,butnotexocytosis,inmousemastcells.
FrumanDAetal(1995)JImmunol154(4):1846-51.PubMedID:7530743CyclosporineAandTacrolimusReducetheAmountofGLUT4attheCellSurfaceinHumanAdipocytes:IncreasedEndocytosisasaPotentialMechanismfortheDiabetogenicEffectsofImmunosuppressiveAgents.
PereiraMJetal(2014)JClinEndocrinolMetab99(10):E1885-94.PubMedID:25004245Modeofactionoftacrolimus(FK506):molecularandcellularmechanisms.
ThomsonAWetal(1995)TherDrugMonit17(6):584-91.PubMedID:8588225
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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