Hello Bio/FK 228/HB1386/5mg
商品编号：
HB1386-5mg
品牌：
hellobio
市场价：
¥9964.50
美元价：
7665.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameFK228
- ShortdescriptionPotent,selectiveHDAC1/HDAC2inhibitor
- BIOLOGicaldescriptionPotentandselectivehistonedeacetylase(HDAC)inhibitor.SelectiveforclassIHDAC1andHDAC2overclassIIHDAC4andHDAC6(IC50valuesare36,47,510nMand14µMrespectively).Induceshumanfetalhemoglobin.Showsgrowthinhibitory,apoptoticandanti-tumoractions.
- AlternativenamesRomidepsin;depsipeptide
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl],cyclic(3-5)disulfide
- MolecularWeight540.7
- Chemicalstructure
![FK 228 [128517-07-7]](images/hellobio/201710/hb1386.png "FK 228 [128517-07-7]")
- MolecularFormulaC24H36N4O6S2
- CASNumber128517-07-7
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforFK228
FK228(depsipeptide)asanaturalprodrugthatinhibitsclassIhistonedeacetylases.
FurumaiRetal(2002)CancerRes62(17):4916-21.PubMedID:12208741EffectsofFK228,anovelhistonedeacetylaseinhibitor,onhumanlymphomaU-937cellsinvitroandinvivo.
SasakawaYetal(2002)BiochemPharmacol64(7):1079-90.PubMedID:12234611HistonedeacetylaseinhibitorFK228isapotentinducerofhumanfetalhemoglobin.
CaoHetal(2006)AmJHematol81(12):981-3.PubMedID:16888791
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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