Hello Bio/Fenobam/HB0286/50mg
商品编号：
HB0286-50mg
品牌：
hellobio
市场价：
¥2515.50
美元价：
1935.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameFenobam
- ShortdescriptionPotent,selective,non-competitivemGlu5antagoNIST
- BIOLOGicaldescriptionPotent,selectiveandnon-competitivemGlu5receptorantagonist.Actsatallostericmodulatorysite(Kdvaluesare54and31nMatratandhumanmGlu5receptorsrespectively).Showsinverseagonistpropertiesonreceptorbasalactivity(IC50value=84nM).Displaysanalgesic,anxiolyticandantidepressanteffects.Orallyactive.
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-(3-Chlorophenyl)-N"-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
- MolecularWeight266.69
- Chemicalstructure
![Fenobam [57653-26-6]](images/hellobio/201710/hb0286.png "Fenobam [57653-26-6]")
- MolecularFormulaC11H11N4O2Cl
- CASNumber57653-26-6
- PubChemidentifier162834
- SMILESCN1CC(=O)N=C1NC(=O)NC2=CC(=CC=C2)Cl
- SourceSynthetic
- InChiInChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h4-5H,6H2,1H3,(H2,13,14,15,17,18)
- InChiKeyDWPQODZAOSWNHB-UHFFFAOYSA-N
- MDLnumberMFCD00868019
- AppearanceYellowsolid
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforFenobam
Fenobam:aclinicallyvalidatednonbenzodiazepineanxiolyticisapotent,selective,andnoncompetitivemGlu5receptorantagonistwithinverseagonistactivity.
PorterRHetal(2005)JPharmacolExpTher315(2):711-21.PubMedID:16040814Antagonistsatmetabotropicglutamatereceptorsubtype5:structureactivityrelationshipsandtherapeuticpotentialforaddiction.
CarrollFI(2008)AnnNYAcadSci1141:221-32.PubMedID:18991960Themetabotropicglutamatereceptorsubtype5antagonistfenobamisanalgesicandhasimprovedinvivoselectivitycomparedwiththeprototypicalantagonist2-methyl-6-(phenylethynyl)-pyridine.
MontanaMCetal(2009)JPharmacolExpTher330(3):834-43.PubMedID:19515968
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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