Hello Bio/Fasudil hydrochloride/HB0283/50mg
商品编号：
HB0283-50mg
品牌：
hellobio
市场价：
¥4192.50
美元价：
3225.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameFasudilhydrochloride
- ShortdescriptionROCKandcyclicnucleotide-dependentproteinkinaseinhibitor
- BIOLOGicaldescriptionRho-associatedkinaseinhibitor(IC50=10.7µM)andcyclicnucleotide-dependentproteinkinaseinhibitor.InhibitsNOSinmicrogliaandpro-inflammatoryfactorsinbraintissue.Alsoreduces nitricoxide,IL-1β,IL-6andTNF.Showsantioxidanteffectswhichcanreversehypertensionandneuroprotectiveactions.
- AlternativenamesHA1077;1-(5-Isoquinolinesulfonyl)homopiperazine,Monohydrochloridesalt
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
- MolecularWeight327.83
- Chemicalstructure
![Fasudil hydrochloride [105628-07-7]](images/hellobio/201710/hb0283.png "Fasudil hydrochloride [105628-07-7]")
- MolecularFormulaC14H17N3O2S.HCl
- CASNumber105628-07-7
- PubChemidentifier163751
- SMILESC1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
- InChiInChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
- InChiKeyLFVPBERIVUNMGV-UHFFFAOYSA-N
- MDLnumberMFCD00943198
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(100mM)andinDMSO(75mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforFasudilhydrochloride
Fasudilprotectshippocampalneuronsagainsthypoxia-reoxygenationinjurybysuppressingmicroglialinflammatoryresponsesinmice.
DingJetal(2010)JNeuRochem114(6):1619-29.PubMedID:20882700FasudilreversedMCT-inducedandchronichypoxia-inducedpulmonaryhypertensionbyattenuatingoxidativestressandinhibitingtheexpressionofTrx1andHIF-1α.
LiuMetal(2014)RespirPhysiolNeurobiol201:38-46.PubMedID:24973470
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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