Hello Bio/ET-18-OCH3/HB0278/100mg
商品编号：
HB0278-100mg
品牌：
hellobio
市场价：
¥9535.50
美元价：
7335.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameET-18-OCH3
- ShortdescriptionSelectivePLCinhibitor
- BIOLOGicaldescriptionSelectivephosphatidylinositolphospholipase(PLC)inhibitor(IC50=9.6µM).Inhibitsmitochondrialrespiration,ERK1/2andp38MAPK.AlsoactivatesFas/CD95deathreceptor.Displaysantitumorandapoptosis-inducingproperties.
- BiologicalactionInhibitor
- Purity>95%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameEdelfosine;1-octadecyl-2-O-methyl-glycero-3-phosphocholine
- MolecularWeight523.7
- Chemicalstructure
![ET-18-OCH3 [77286-66-9]](images/hellobio/201710/hb0278.png "ET-18-OCH3 [77286-66-9]")
- MolecularFormulaC27H58NO6P
- CASNumber77286-66-9
- PubChemidentifier6918215
- SMILESCCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC
StoringandUsingYourProduct
- SolubilityoverviewsolubleinethanolorDMSO
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforET-18-OCH3
ET-18-OCH3(edelfosine):aselectiveantitumourlipidtargetingapoptosisthroughintracellularactivationofFas/CD95deathreceptor.
MollinedoFetal(2004)CurrMedChem11(24):3163-84.PubMedID:15579006SelectiveinhibitionofphosphatidylinositolphospholipaseCbycytotoxicetherlipidanalogues.
PowisGetal(1992)CancerRes52(10):2835-40.PubMedID:1316230EdelfosineandperifosinedisrupthepaticmitochondrialoxidativephosphorylationandinducethepermeABIlitytransition.
BurgeiroAetal(2013)Mitochondrion13(1):25-35.PubMedID:23164800Theantitumoretherlipidedelfosine(ET-18-O-CH3)inducesapoptosisinH-rastransformedhumanbreastepithelialcells:byblockingERK1/2andp38mitogen-activatedproteinkinasesaspotentialtargets.
NaHKetal(2008)AsiaPacJClinNutr17Suppl1:204-7.PubMedID:18296338
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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