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Hello Bio/D-erythro-N,N-Dimethylsphingosine/HB0237/100mg
Hello Bio/D-erythro-N,N-Dimethylsphingosine/HB0237/100mg
商品编号：
HB0237-100mg
品牌：
hellobio
市场价：
¥12363.00
美元价：
9510.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameD-erythro-N,N-Dimethylsphingosine
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Short descriptionSphingosine kinase inhibitor
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Biological descriptionCompetitive sphingosine kinase inhibitor (IC50 = 5 µM). Also inhibits protein kinase C (PKC). Shows cardioprotective, apoptotic and anti-cancer actions.
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Alternative namesDMS
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Molecular Weight327.5
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Chemical structure
![D-erythro-N,N-Dimethylsphingosine [119567-63-4]](images/hellobio/201710/hb0237.png "D-erythro-N,N-Dimethylsphingosine [119567-63-4]")
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Molecular FormulaC20H41NO2
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CAS Number119567-63-4
Storing and Using Your Product
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Solubility overviewsoluble in ethanol (25mg/ml) or DMSO (25mg/ml)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for D-erythro-N,N-Dimethylsphingosine
Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.
Jin ZQ et al (2006) Cardiovasc Res 71(4) : 725-34.PubMedID: 16831409Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.
Sweeney EA et al (1996) Int J Cancer 66(3) : 358-66.PubMedID: 8621258D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells.
Xu CB et al (2002) Atherosclerosis 164(2) : 237-43.PubMedID: 12204793Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities.
Igarashi Y et al (1989) Biochemistry 28(17) : 6796-800.PubMedID: 2479412
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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