Hello Bio/Eplerenone/HB2527/50mg
商品编号：
HB2527-50mg
品牌：
hellobio
市场价：
¥6240.00
美元价：
4800.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameEplerenone
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Short descriptionSelective mineralcorticoid receptor antagonist
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Biological descriptionSelective mineralcorticoid receptor antagonist (IC50 = 990 nM). Shows little to no effect at androgen, estrogen or progesterone receptors. Shows cardioprotective and anti-apoptotic effects.
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Biological actionAntagonist
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Purity>99%
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Properties
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Chemical name(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-o xo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
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Molecular Weight414.5
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Chemical structure
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Molecular FormulaC24H30O6
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CAS Number107724-20-9
Storing and Using Your Product
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Storage instructionsroom temperature
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Eplerenone
Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
McMahon EG (2001) Curr Opin Pharmacol 1(2) : 190-6.PubMedID: 11714095A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.
Fagart J et al (2010) J Biol Chem 285(39) : 29932-40.PubMedID: 20650892Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes.
Ramã?rez E et al (2013) Cardiovasc Diabetol 12 : 172PubMedID: 24261558
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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