你好Bio/Eliprodil/HB0274/10mg
商品编号：
HB0274-10mg
品牌：
hellobio
市场价：
¥1209.00
美元价：
930.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameEliprodil
- ShortdescriptionNon-competitive,GluN2BsubunitselectiveNMDAreceptorantagoNIST
- BIOLOGicaldescriptionNon-competitiveandGluN2BsubunitselectiveNMDAreceptorantagonist.Bindsatthepolyaminesite.IC50valuesare1,>100and>100µMforGluN2B,GluN2AandGluN2Crespectively.AlsoInhibitsvoltage-dependentCa2+channels.ShowsneuroprotectiveactionsandpotentiatesanticonvulsanteffectsofCGP37849.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalnameα-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
- MolecularWeight347.86
- Chemicalstructure
![Eliprodil [119431-25-3]](images/hellobio/201710/hb0274.png "Eliprodil [119431-25-3]")
- MolecularFormulaC20H23ClFNO
- CASNumber119431-25-3
- PubChemidentifier60703
- SMILESC1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O
- InChiInChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2
- InChiKeyGGUSQTSTQSHJAH-UHFFFAOYSA-N
- MDLnumberMFCD00866651
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewSolubleinDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforEliprodil
Preventionbyeliprodil(SL82.0715)oftraumaticbraindamageintherat.Existenceofalarge(18h)therapeuticwindow.
ToulmondSetal(1993)Preventionbyeliprodil(SL82620(1):32-41.PubMedID:8402196AntagonismofNMDAreceptorsbysigmasiteligands:potency,subtype-selectivityandmechanismsofinhibition.
WhittemoreERetal(1997)JPharmacolExpTher282(1):326-38.PubMedID:9223571CentraleffectsofSL82.0715,anantagonistofpolyaminesiteoftheNMDAreceptorcomplex.
Dereń-WesołekAetal(1993)CentraleffectsofSL8245(5-6):467-80.PubMedID:7912135Theeffectsofifenprodilandeliprodilonvoltage-dependentCa2+channelsandingerbilglobalcerebralischaemia.
BathCPetal(1996)EurJPharmacol299(1-3):103-12.PubMedID:8901012
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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