Hello Bio/EHNA hydrochloride/HB3540/10mg
商品编号：
HB3540-10mg
品牌：
hellobio
市场价：
¥1053.00
美元价：
810.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameEHNA hydrochloride
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Short descriptionPotent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation.
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Biological descriptionPotent adenosine deaminase (ADA) and PDE2 inhibitor (Ki = 1.6 nM at ADA and IC50 values are 0.8 and 4 ΜM at human and porcine PDE2 respectively. Reversibly supresses spontaneous hESCs differentiation. Also acts as a strong blocker of directed neuronal differentiation.
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical nameerythro-9-(2-Hydroxy-3-nonyl)adenin e hydrochloride
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Molecular Weight313.83
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Chemical structure
![EHNA hydrochloride | [58337-38-5]](images/hellobio/201710/hb3540.png "EHNA hydrochloride | [58337-38-5]")
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Molecular FormulaC14H23N5O.HCl
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CAS Number58337-38-5
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in water (100mM) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for EHNA hydrochloride
Probing the active site of adenosine deaminase by a pH responsive fluorescent competitive inhibitor.
Caiolfa et al (1998) Biophys Chem 70(1) : 41-56PubMedID: 9474762Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.
Burton et al (2010) Biochem J 432(3) : 575-84PubMedID: 20923411Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats.
Woodson et al (1998) Behav Neurosci 112(2) : 339-409PubMedID: 9588486
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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