Hello Bio/E6 Berbamine/HB0269/10mg
商品编号：
HB0269-10mg
品牌：
hellobio
市场价：
¥1696.50
美元价：
1305.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameE6Berbamine
- ShortdescriptionPotent,selectiveCaMantagoNIST
- BIOLOGicaldescriptionPotentandselectivecalmodulin(CaM)antagonist.InhibitsMLCKactivity(Ki=0.95µM)andP-glycoprotein(P-gp)activityinvascularendothelialcells.Inhibitsα3-containingneuronalnicotinicacetylcholinereceptors(α3-nAChRs).Cell-permeable.
- AlternativenamesE6;BerbaminecompoundE6
- BiologicalactionAntagonist
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6,6",7-Trimethoxy-2,2"-dimethylberbaman-12-ylacetate;Calmodulininhibitor
- MolecularWeight757.83
- Chemicalstructure
![E6 Berbamine [73885-53-7]](images/hellobio/201710/hb0269.png "E6 Berbamine [73885-53-7]")
- MolecularFormulaC44H43N3O9
- CASNumber73885-53-7
StoringandUsingYourProduct
- SolubilityoverviewsolubleinDMSO(25mg/ml)orethanol(25mg/ml)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforE6Berbamine
InteractionofberbaminecompoundE6andcalmodulin-dependentmyosinlightchainkinase.
HuZYetal(1992)BiochemPharmacol44(8):1543-7.PubMedID:1417979EffectofE6,anovelcalmodulininhibitor,onactivityofP-glycoproteininpurifiedprimaryculturedratbrainmicrovesselendothelialcells.
ZhuHJetal(2003)ActaPharmacolSin24(11):1143-9.PubMedID:14627500Differentialinhibitionofratalpha3*andalpha7nicotinicacetylcholinereceptorsbytetrandrineandcloselyrelatedbis-benzylisoquinolinederivatives.
VirginioCetal(2005)NeurosciLett381(3):299-304.PubMedID:15896488
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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