Hello Bio/E-4031 dihydrochloride/HB1080/50mg
商品编号：
HB1080-50mg
品牌：
hellobio
市场价：
¥7507.50
美元价：
5775.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameE-4031dihydrochloride
- ShortdescriptionPotent,selectiveKv11.1channelblocker
- BIOLOGicaldescriptionPotentandselectiveKv11.1(hERG)channelblocker(IC50=7.7nMinHEK293cells).DelayedrectifierK2+currentinhibitor.Showsantiarrhythmicactions.
- BiologicalactionBlocker
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamidedihydrochloride
- MolecularWeight474.44
- Chemicalstructure
![E-4031 dihydrochloride [113559-13-0]](images/hellobio/201710/hb1080.png "E-4031 dihydrochloride [113559-13-0]")
- MolecularFormulaC21H27N3O3S.2HCl
- CASNumber113559-13-0
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- Solubilityoverviewsolubleinwater(100mM)orDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforE-4031dihydrochloride
PostnataldevelopmentofE-4031-sensitivepotassiumcurrentinratcarotidchemoreceptorcells.
KimIetal(2005)JApplPhysiol(1985)98(4):1469-77.PubMedID:15591286EffectsofthenewclassIIIantiarrhythmicdrugE-4031onmyocardialcontractilityandelectrophysiologicalparameters.
WettwerEetal(1991)JCardiovascPharmacol17(3):480-7.PubMedID:1711611PropertiesofHERGchannelsstablyexpressedinHEK293cellsstudiedatphysiologicaltemperature.
ZhouZetal(1998)BiophysJ74(1):230-41.PubMedID:9449325
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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