Hello Bio/Dynasore/HB1245/50mg
商品编号：
HB1245-50mg
品牌：
hellobio
市场价：
¥4914.00
美元价：
3780.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDynasore
- ShortdescriptionCellpermeable,potentandselectivedynaminGTPaseinhibitor
- BIOLOGicaldescriptionCellpermeable,potentandselectivedynaminGTPaseinhibitor.Actsinnon-competitivereversIBLemanner.Displaysactivityforbothdynamin1,dynamin2(approxIC50value=15µMrespectively)andmitochondrialdynamin(DRP1).ExhibitslittleornoactivityatothersmallGTPases.Blocksendocytosis.Inhibitstransferrinuptake(IC50=15µM)andpotentlydestABIlisesF-actin.Displayscardioprotectiveproperties
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-Hydroxynaphthalene-2-carboxylicacid(3,4-dihydroxybenzylidene)hydrazide
- MolecularWeight322.32
- Chemicalstructure
![Dynasore [304448-55-3]](images/hellobio/201710/hb1245.png "Dynasore [304448-55-3]")
- MolecularFormulaC18H14N2O4
- CASNumber304448-55-3
- SMILESOc3ccc(/C=N/NC(=O)c1cc2ccccc2cc1O)cc3O
StoringandUsingYourProduct
- Storageinstructions-20°C
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDynasore
Dynasore,adynamininhibitor,suppresseslamellipodiaformationandcancercellinvasionbydestabilizingactinfilaments.
YamadaHetal(2009)BiochemBiophysResCommun390(4):1142-8.PubMedID:19857461DynasoreprotectsmitochondriaandimprovescardiaclusitropyinLangendorffperfusedmouseheart.
GaoDetal(2013)PLoSOne8(4):e60967.PubMedID:23596510Dynasoreinhibitsremovalofwild-typeandDeltaF508cysticfibrosistransmembraneconductanceregulator(CFTR)fromtheplasmamembrane.
YoungAetal(2009)BiochemJ421(3):377-85.PubMedID:19442237Dynasore,acell-permeableinhibitorofdynamin.
MaciaEetal(2006)DevCell10(6):839-50.PubMedID:16740485
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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