你好Bio/DPCPX/HB2094/100mg
商品编号：
HB2094-100mg
品牌：
hellobio
市场价：
¥1345.50
美元价：
1035.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameDPCPX
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Short descriptionPotent, selective A1 receptor antagonist
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Biological descriptionPotent and selective A1 adenosine receptor antagonist (Ki values are 0.45 and 300 nM at A1 and A2 receptors respectively). Active in vivo. Facilitates long term potentiation (LTP) and blocks induction of long term depression (LTD).
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Biological actionAntagonist
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Purity>98%
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Properties
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Chemical name8-Cyclopentyl-1,3-dipropylxanthine
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Molecular Weight304.39
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Chemical structure
![DPCPX [102146-07-6]](images/hellobio/201710/hb2094_2.png "DPCPX [102146-07-6]")
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Molecular FormulaC16H24N4O2
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CAS Number102146-07-6
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PubChem identifier1329
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SMILESCCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3
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SourceSynthetic
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InChiInChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
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InChiKeyFFBDFADSZUINTG-UHFFFAOYSA-N
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MDL numberMFCD00055117
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AppearanceWhite solid
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in DMSO (5 mM) and in ethanol (10 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for DPCPX
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
von der Leyen et al (1989) Naunyn Schmiedebergs Arch Pharmacol. 340(2) : 204-9PubMedID: 25541518-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.
Lohse et al (1987) Naunyn Schmiedebergs Arch Pharmacol. 336(2) : 204-10PubMedID: 2825043Caffeine, adenosine receptors, and synaptic plasticity.
Costenla et al (2010) J Alzheimers Dis 1 : S25-34PubMedID: 20182030Activation of receptors negatively coupled to adenylate cyclase is required for induction of long-term synaptic depression at Schaffer collateral-CA1 synapses.
Santschi et al (2006) J Neurobiol 66(3) : 205-19PubMedID: 16329119
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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