Hello Bio/Dorsomorphin dihydrochloride/HB2800/50mg
商品编号：
HB2800-50mg
品牌：
hellobio
市场价：
¥7449.00
美元价：
5730.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDorsomorphindihydrochloride
- ShortdescriptionPotent,selectiveAMPKinhibitor.Alsopromotescardiomyocytedifferentiationinmouseembroynicstemcells(mESCs).
- BIOLOGicaldescriptionPotent,selectiveandreversIBLeAMPKinhibitor(Ki=109nM).InhibitsAICARandmetformininducedAMPKactivation.AdditionallyshowsactivityatALK2,ALK3andALK6.Alsopromotescardiomyocytedifferentiationinmouseembroynicstemcells(mESCs).
- AlternativenamesCompoundC|BML-275
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidinedihydrochloride
- MolecularWeight472.41
- Chemicalstructure
![Dorsomorphin dihydrochloride | Compound C, BML-275 [1219168-18-9]](images/hellobio/201710/hb2800.png "Dorsomorphin dihydrochloride | Compound C, BML-275 [1219168-18-9]")
- MolecularFormulaC24H25N5O.2HCl
- CASNumber1219168-18-9
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- Solubilityoverviewsolubleinwater(100mM)orDMSO(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDorsomorphindihydrochloride
RoleofAMP-activatedproteinkinaseinmechanismofmetforminaction.
Zhouetal(2001)JClinInvest108(8):1167-74PubMedID:11602624CompoundCinducesprotectiveautophagyincancercellsthroughAMPKinhibition-independentblockadeofAkt/mTORpathway.
Vucicevicetal(2011)Autophagy7(1):40-50PubMedID:20980833Dorsomorphin,aselectivesmallmoleculeinhibitorofBMPsignaling,promotescardiomyogenesisinembryonicstemcells.
Haoetal(18682835)PLoSOne3(8):e2904
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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