Hello Bio/Dofetilide/HB1078/10mg
商品编号：
HB1078-10mg
品牌：
hellobio
市场价：
¥1579.50
美元价：
1215.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDofetilide
- ShortdescriptionSelectivepotassiumchannelblocker
- BIOLOGicaldescriptionSelectivepotassiumchannelblocker.InhibitsKv11.1(hERG)channels(IC50=0.32µM)andrapiddelayed-rectifierK+current(IKr).Increasesthedurationandrefractoryperiodofcardiacactionpotentials.ShowsclassIIIantiarrhythmicactions.
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
- MolecularWeight441.56
- Chemicalstructure
![Dofetilide [115256-11-6]](images/hellobio/201710/hb1078.png "Dofetilide [115256-11-6]")
- MolecularFormulaC19H27N3O5S2
- CASNumber115256-11-6
- PubChemidentifier71329
- SMILESCN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
- InChiInChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
- InChiKeyIXTMWRCNAAVVAI-UHFFFAOYSA-N
- MDLnumberMFCD00869707
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDofetilide
UK-68,798:anovel,potentandhighlyselectiveclassIIIantiarrhythmicagentwhichblockspotassiumchannelsincardiaccells.
GwiltMetal(1991)JPharmacolExpTher256(1):318-24.PubMedID:1988662Moleculardeterminantsofinactivationanddofetilideblockinethera-go-go(EAG)channelsandEAG-relatedK(+)channels.
FickerEetal(2001)MolPharmacol60(6):1343-8.PubMedID:11723241Effectsoftheantiarrhythmicdrugdofetilideontransmuraldispersionofrepolarizationinventriculum.Acomputermodelingstudy.
SaizJetal(2011)IEEETransBiomedEng58(1):43-53.PubMedID:20851784Voltage-andtime-dependentblockofthedelayedK+currentincardiacmyocytesbydofetilide.
CarmelietE(1992)JPharmacolExpTher262(2):809-17.PubMedID:1501123
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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